Salicylic acid can also be prepared using the Kolbe-Schmitt reaction. Meat, poultry, fish, eggs, oils, dairy products, sugar, cereals, and flour all have little to no salicylates. Acidification of the product with sulfuric acid gives salicylic acid: Other uses[ edit ] Salicylic acid is used as a food preservativea bactericidal and an antiseptic.
Salicylic acid was one of the original starting materials for making acetylsalicylic acid aspirin in Safety[ edit ] As a topical agent and as a beta-hydroxy acid and unlike alpha-hydroxy acidssalicylic acid is capable of penetrating and breaking down fats and lipids, causing moderate chemical burns of the skin at very high concentrations.
It may damage the lining of pores if the solvent is alcohol, acetone or an oil.
If high concentrations of salicylic ointment are applied to a large percentage of body surface, high levels of salicylic acid can enter the blood, requiring hemodialysis to avoid further complications.
Medical uses of salicylic acid Cotton pads soaked in salicylic acid can be used to chemically exfoliate skin Salicylic acid as a medication is used most commonly to help remove the outer layer of the skin. A recent study using best practice measurement methodology significantly reduced intra-sample measurement variability but has not yet been replicated or extended.
In Arabidopsis thaliana it can be synthesized via a phenylalanine-independent pathway. Dietary sources[ edit ] Salicylic acid occurs in plants as free salicylic acid and its carboxylated esters and phenolic glycosides.
The signal can also move to nearby plants by salicylic acid being converted to the volatile ester methyl salicylate. Several studies suggest that humans metabolize salicylic acid in measurable quantities from these plants;  one study found that vegetarians not taking aspirin had urinary levels of salicylic acid higher than the non-vegetarians.
It is easily prepared on a clean surface by spraying a saturated solution of the salt in methanol followed by evaporation. Sodium salicylate is commercially prepared by treating sodium phenolate the sodium salt of phenol with carbon dioxide at high pressure atm and high temperature K — a method known as the Kolbe-Schmitt reaction.
It can also be prepared by the hydrolysis of aspirin acetylsalicylic acid  or methyl salicylate oil of wintergreen with a strong acid or base.
History of aspirin White willow Salix alba is a natural source of salicylic acid HippocratesGalenPliny the Elder and others knew that willow bark could ease pain and reduce fevers. It is also known as 2-hydroxybenzoic acid.A Student Researched Lab Analysis about the Synthesis of Salicylic Acid from Wintergreen Oil.
Salicylic Acid preparation Lab 1 Experiment #1: Synthesis of Salicylic Acid From Wintergreen Oil By: Here are the physical properties of Salicylic Acid and the mechanism of reactions that occurred in this lab.
How Salicylic Acid is derived: Procedure/Results First. Salicylic acid (from Latin salix, willow tree) is a lipophilic monohydroxybenzoic acid, a type of phenolic acid, and a beta hydroxy acid (BHA).
It has the formula C 7 H 6 O 3. This colorless crystalline organic acid is widely used in Melting point: °C ( °F; K). PREPARATION OF ACETYLSALICYLIC ACID (ASPIRIN) BACKGROUND Acetylsalicylic Acid (Aspirin) Fig. 1: Aspirin vs. Salicylic Acid 4. Post-lab Questions a) What was used to increase the rate of the reaction?
b) What would happen to your percent yield if the aspirin you prepared was not dried completely?. SYNTHESIS AND ANALYSIS OF ASPIRIN LAB ADV COMP 22 From Advanced Chemistry with Vernier, Vernier Software & Technology, You will mix iron (III) nitrate with salicylic acid and your aspirin sample to complex the salicylic acid, which is a bluish-purple color.
You will analyze several samples to. The purpose of this lab experiment is to prepare salicylic acid from the natural starting material, methyl salicylate, and compare it with the salicylic acid produced from the artificial compound benzene (obtained through petroleum refining).Download